Nimbolide Inhibits Cell Survival and Proliferation of IGF1 Mediated PI3K-Akt and MAPK Signaling in Human Breast Cancer Cells and TNF-Α/TNFR1 Mediated Signaling Molecules in Prostate Cancer

Nimbolide was first derived from the leaves and flowers of need. Neem Azadirachtaindica is a traditional medicinal plant of the Meliaceaefamily widely distributed in Asia, Africa and other tropical parts for the world. Studies of extracts from leaves, flowers, fruits and seeds have shown promising chemo preventive and therapeutic effects in pre-clinical research [1-2]. Demonstrated that extracts of Neem leaf have been reported to be non-toxic and non-mutagenic and are found to possess immunomodulatory as well as anti-inflammatory and anti-carcinogenic properties. Anticancer effects of ethanolic Neem leaf extracts on prostate cancer cell line have also been studied in our laboratory [3]. Our previous studies also demonstrated that induction of apoptosis and inhibition of PI3K/Akt pathway in androgen dependent and androgen independent prostate cancer cells by ethanolic Neem leaf extract [4]. Ethanolic Neem leaf extract induces apoptosis and inhibits the IGf signaling pathway in breast cancer cell line [5].